Despite the name, a REJURAN facial is not as unusual as it may initially sound. The treatment is more accurately known as a polynucleotide (PN) or PDRN therapy, which uses purified DNA fragments derived from salmon to support skin repair and rejuvenation. This approach has become an emerging dermatological treatment across the globe, particularly for concerns related to ageing, skin damage, and overall texture.
PDRN has been studied extensively, and research shows that it works by stimulating fibroblasts (the cells responsible for producing collagen) and by accelerating natural healing processes. The result is improved skin healing, increased elasticity, and gradual restoration of a healthier skin barrier.
This article outlines what the treatment involves, how it works, the potential benefits, and what a typical session may look like.
Key Takeaways
- Salmon DNA is 95% compatible with human DNA, allowing effective skin regeneration without triggering immune responses or allergic reactions in most patients.
- Treatment stimulates collagen production and reduces inflammation by activating A2A receptors and fibroblasts, leading to improved hydration, elasticity, and reduced fine lines.
- Multiple application methods available: topical, microneedling, or direct injection, with injectable methods delivering the highest concentration of regenerative benefits.
- Minimal downtime with temporary side effects, including mild redness and swelling that typically resolve within 24-72 hours after treatment.
- Optimal results require 3-4 initial treatments spaced 2-4 weeks apart, followed by maintenance sessions every 6-9 months for sustained benefits.
What is a REJURAN Facial?
REJURAN may sound unusual, but the treatment is not what the name suggests. It does not involve raw fish or unprocessed biological material. Instead, the therapy uses highly purified DNA fragments that are carefully extracted from salmon sperm cells. In clinical skincare, this ingredient is known as polynucleotide (PN) or polydeoxyribonucleotide (PDRN).
Although the terms are sometimes used interchangeably, they refer to slightly different forms of DNA-based skincare:
- PDRN (Polydeoxyribonucleotide) consists of shorter DNA fragments. These help stimulate the regeneration of skin cells and support the healing process. They work by activating specific receptors in the skin that reduce inflammation and encourage tissue repair.
- PN (Polynucleotide) refers to longer DNA fragments. Because of their size, PN-based products are typically administered through injectable treatments rather than being absorbed through topical application.
Both types are used for skin rejuvenation, but the method and depth of delivery can vary between treatments.
How the Ingredient Is Processed
The DNA used in these treatments undergoes an intensive purification process. Scientists isolate the sperm cells from salmon testis and remove any proteins, peptides, or biological components that could cause irritation or allergic reactions. What remains is a sterile, pharmaceutical-grade DNA extract that is formulated specifically for safe use on human skin.
This purified DNA is significantly cleaner and more stable than many other biological skincare ingredients, which helps ensure treatment consistency and safety.
Why Salmon DNA Works Well with Human Skin
Salmon DNA has a high level of structural compatibility with human DNA, around 95%. Because of this similarity, the skin can recognise and integrate the DNA fragments without treating them as foreign material. This allows the ingredient to support natural cellular repair processes.
People with seafood or fish allergies can typically still receive PN or PDRN treatments because the purification removes proteins and other components that normally trigger allergic responses.
How Does It Work on the Skin?
Polynucleotide therapy supports the skin’s natural repair processes at a cellular level. The active ingredient (polynucleotide (PN) or PDRN) works through mechanisms that have been studied in dermatology and regenerative medicine.
- Stimulating Fibroblasts and Collagen Production: Within the skin, fibroblasts are responsible for producing collagen, elastin, and hyaluronic acid. PDRN helps stimulate these fibroblasts, encouraging them to work more efficiently. Over time, this can improve skin firmness, elasticity, and hydration, while supporting a smoother overall texture.
- A2A Receptor Activation: The treatment also activates adenosine A2A receptors in the skin. These receptors play a role in reducing inflammation and supporting tissue repair. When activated, they help calm irritated skin, promote healthier blood flow, and encourage new cell growth. This makes the treatment suitable for individuals with sensitive or reactive skin.
- Supporting Cellular Repair Through the Salvage Pathway: The polynucleotides in the treatment provide building blocks that the skin can use to repair damaged cells. Instead of creating new DNA components from scratch, the skin can recycle these fragments to support regeneration. This process may be particularly beneficial for skin that has experienced ageing, sun exposure, or environmental stress.
Application Methods and What to Expect
Polynucleotide treatments can be delivered in different ways. The practitioner will recommend an approach based on skin concerns, desired outcome, and comfort level:
| Method | How It Works | Best For |
| Topical Application | This method involves applying the polynucleotide serum directly to the skin’s surface.
The product is smoothed onto clean skin and allowed to absorb. While topical application on its own does not allow the ingredient to reach the deeper layers, it can still support surface hydration and barrier repair. |
Individuals seeking gentle improvements in hydration, radiance, and overall skin comfort. This approach is often used as part of a facial treatment or to maintain results between more intensive procedures. |
| Microneedling with PDRN | Microneedling is commonly paired with PDRN to improve absorption.
A microneedling device creates controlled micro-channels on the skin’s surface. The PDRN solution is then applied so it can enter deeper layers of the skin. The micro-channels allow the active ingredient to reach areas where collagen and elastin production occur. This supports more noticeable improvements than topical use alone. |
Individuals targeting uneven texture, fine lines, enlarged pores, or mild scarring. This method offers a balance between visible results and minimal downtime. |
| Injectable PN/PDRN | This method delivers the ingredient directly into the targeted layers of skin through a series of micro-injections.
Small, precise injections place the polynucleotides into the dermis, the layer where collagen, elastin, and structural support are formed. By placing the ingredient directly where cellular repair occurs, the treatment can support more pronounced improvements in firmness, elasticity, and overall rejuvenation. |
Individuals seeking deeper or more noticeable results, such as softening fine lines, improving skin laxity, or addressing scarring or visible signs of ageing. |
Comfort and Sensation
Most people experience mild pressure or light stinging during the procedure, especially with injectables. Any sensation usually eases soon after the session.
Recovery and Aftercare
Mild redness or swelling may occur, particularly after microneedling or injections. These effects generally settle within 1–2 days. To support healing:
- Avoid direct sun exposure for at least 48 hours.
- Hold off on exfoliants, retinoids, or strong active ingredients for 3–5 days.
- Use gentle, hydrating skincare.
Ongoing Maintenance
Most treatment plans begin with a series of sessions spaced 2–4 weeks apart. Once initial improvements are established, maintenance every 6–9 months can help sustain results. How long results last will depend on age, skin condition, and lifestyle factors, but many people notice benefits for several months.
Demonstrated Benefits of REJURAN (PDRN) Treatment
By working at a cellular level, polynucleotides (PN) and PDRN help improve multiple aspects of skin health and appearance, delivering consistent results across hydration, elasticity, and overall skin quality.
Improved Hydration and Skin Barrier
Polynucleotides help the skin retain moisture more effectively, supporting a stronger, healthier skin barrier. Research confirms that salmon DNA promotes hydration by increasing the skin’s ability to hold water, resulting in plumper, smoother skin. Maintaining optimal hydration is essential for preventing dryness, flakiness, and early signs of ageing.
Reduction in Fine Lines and Wrinkles
Polynucleotide therapy stimulates fibroblasts (the cells responsible for collagen and elastin production), helping to reduce the appearance of fine lines and wrinkles. The treatment also inhibits enzymes called matrix metalloproteinases (MMPs), which can break down collagen over time. As a result, skin elasticity improves, and signs of ageing are diminished.
Enhanced Elasticity and Firmness
By boosting collagen and elastin production, PDRN supports the skin’s structural integrity. This leads to thicker, firmer skin with better resilience and elasticity. With regular treatments, many clients notice lasting improvements in skin vitality and a greater ability to withstand environmental stressors.
Anti-Inflammatory Effects for Sensitive Skin
PDRN has anti-inflammatory properties that can help calm redness, swelling, and irritation. By reducing pro-inflammatory cytokines and supporting anti-inflammatory pathways, REJURAN facials are suitable for sensitive skin types, including those prone to rosacea or other inflammatory conditions. This contributes to a more even and balanced skin tone.
Risks, Side Effects, and Safety Considerations
REJURAN facials are generally considered safe when administered by qualified professionals. They are designed to work at a cellular level, supporting skin regeneration without introducing harmful substances. Clinical evidence and practitioner experience suggest that side effects are typically mild and temporary. However, understanding potential reactions and safety considerations is important before undergoing treatment.
Common Side Effects
Most side effects stem from the delivery method (such as microneedling or injections) rather than the PDRN compound itself. These reactions are usually mild, short-lived, and resolve within 24–72 hours:
- Redness and Swelling: Treated areas may appear red or slightly swollen immediately after the procedure. This is a normal response as the skin begins its regenerative process.
- Raised Bumps or Papules: Small, temporary bumps may form at injection sites. These usually subside within a day or two.
- Minor Bruising: Pinprick marks from injections can occasionally cause slight bruising, particularly in areas with thinner skin.
- Temporary Dryness: As the skin regenerates, some individuals notice mild dryness or tightness in the treated areas. Applying gentle, hydrating skincare products can alleviate discomfort.
Cold compresses or ice packs can help minimise swelling and discomfort in the first 24 hours. Following provider guidance on aftercare can also reduce the likelihood of prolonged irritation.
Who Should Avoid Polynucleotide Therapy
While most people tolerate PDRN treatments well, certain conditions or situations make the procedure inadvisable:
- Active Skin Issues: Individuals with open wounds, infections, severe acne flare-ups, or sunburn should postpone treatment until the skin has fully healed.
- Pregnancy and Breastfeeding: Safety during pregnancy and lactation has not been fully established. It is recommended to defer treatment during this period.
- Autoimmune or Systemic Conditions: People with autoimmune skin disorders or other systemic conditions affecting the skin may face increased risks.
- Recent Skin Procedures: Treatments like chemical peels, laser therapy, or other invasive procedures within the past 2–4 weeks can increase sensitivity and should be considered before scheduling a PDRN session.
- Bleeding or Clotting Disorders: Individuals with bleeding disorders or those taking blood-thinning medications may experience more noticeable bruising or bleeding at injection sites.
- Severe Inflammatory Skin Conditions: Eczema, psoriasis flares, or other significant inflammatory skin conditions may worsen with treatment, so consultation with a healthcare professional is advised.
Despite the source material being derived from fish, people with seafood allergies generally tolerate salmon DNA treatments without complications. The extensive purification process removes most proteins and potential allergens, making the treatment safe for these individuals under professional supervision.
Key Takeaways
REJURAN offers a scientifically supported approach to enhancing skin repair and rejuvenation. By using polynucleotides (PDRN), these treatments can stimulate collagen production, improve hydration, and reduce inflammation, supporting overall skin health at a cellular level.
However, deciding whether this treatment is right depends on individual factors such as skin condition, personal goals, budget, and comfort with the procedure.
By weighing these considerations alongside the documented benefits, individuals can make an informed choice about incorporating REJURAN facials into their skincare routine. For those seeking targeted, science-based skin rejuvenation, PDRN treatments offer a credible and innovative option.
Esteem Clinic is recognised for its expertise in advanced aesthetic procedures, employing evidence-based techniques and medical-grade skincare products. Prospective patients are encouraged to schedule a consultation to determine whether a REJURAN (PDRN) facial is appropriate for their individual skin needs.
Disclaimer:
This information is intended for educational purposes only. It is not promotional and does not recommend or encourage any treatment.
All treatments carry risks. Results vary depending on factors such as genetics, lifestyle, and anatomy. The information provided here is not a substitute for personal medical advice, diagnosis, or treatment. Any procedure can only be considered after a consultation with a qualified professional, where risks and suitability are assessed.
